Monoclonal antibody treatment for COVID-19

There is now a treatment available that can help keep some people from getting very sick or going to the hospital. It is called monoclonal antibody (mAb) treatment or therapy. Monoclonal antibodies do not take the place of a COVID-19 vaccine. Getting vaccinated is the best way to prevent getting sick with COVID-19. 

Get care early

Monoclonal antibody treatment must be taken early in your illness or shortly after you are exposed to COVID-19. Monoclonal antibody treatment isn’t right for everyone and needs to be ordered by a doctor or clinic. Talk to your healthcare provider right away about what is right for you. If you don’t have a health care provider, call 211 for help finding one.

What is monoclonal antibody treatment?

Monoclonal antibody treatment is a type of medicine given to someone who has been exposed to COVID-19 or who is mildly or moderately sick with COVID-19 and is NOT hospitalized. The treatment is a fluid given using a needle either into a vein or under the skin.


Monoclonal antibodies are proteins produced in a lab that are designed to work like the antibodies (disease-fighting proteins) made by your own body. The proteins attach to a spike protein on the outside of the COVID-19 virus. This blocks the virus from entering your cells, stopping the infection from spreading before it causes severe illness.  

Is this a new treatment? 

Using monoclonal antibodies to treat COVID-19 is new, because COVID-19 is new. However, monoclonal antibodies have been tested and used for many years to treat some types of cancer and autoimmune diseases, as well as rabies, Ebola, and other illnesses. 


Monoclonal antibody treatment works against the Delta variant of COVID-19. The U.S. Food and Drug Administration (FDA) authorized monoclonal antibody treatment for emergency use for COVID-19 patients who are at risk for serious illness from the virus.

Who is eligible for monoclonal antibody treatment? 

To receive monoclonal antibody treatment, you must be 12 years old or older and weigh more than 88 pounds (40 kilograms).

  • Have tested positive for COVID-19
  • Be within 10 days of starting to have symptoms
  • Have mild to moderate symptoms
  • Not be hospitalized for COVID-19
  • Not be on new or increased oxygen therapy
  • And be considered a high-risk patient (see below)

High risk conditions include: 

  • Any medical condition or other factor, including race or ethnicity, that puts you at higher risk of getting severe COVID-19
  • 65 years of age or older
  • Obesity or being overweight
  • Pregnancy
  • Some ongoing diseases like kidney disease, diabetes, heart disease, high blood pressure, sickle cell disease, or lung disease
  • Disease or treatments that lower your immune response
  • Certain neurological or developmental disorders
  • Having a medical-related dependence on technology

What is in monoclonal antibody treatment?

In addition to the antibody protein, the treatment contains water, sugar, salt, a common stabilizer often used in foods and cosmetics (polysorbate 80), and amino acids.  


The treatment does not contain eggs, pork products, latex or fetal cells.

How much does it cost? 

Monoclonal antibodies for COVID are covered by the Oregon Health Plan and other insurance providers and should be low or no cost to you. Clinics can charge to administer the treatment, so check with your insurer and the clinic where you are receiving treatment to find out if there will be any cost to you.  

What to expect from monoclonal antibody treatment? 

There are two ways to administer a monoclonal antibody treatment. Both use needles and must be given by a trained medical professional. One is given by infusion into a vein, the other is given subcutaneously under the skin. Your healthcare provider or person giving the treatment will explain which type you are getting. For more information about the treatment and side effects, see our “after treatment” page.

How do I get this treatment? 

Many healthcare providers are offering monoclonal antibody treatment. Contact your provider to see if they are providing this therapy or if they can refer you to receive it. You may also contact Tuality Physicians at 503-640-3724. 


For more information about monoclonal antibodies 

  • Visit the COMBAT COVID  U.S. Health & Human Services page.
  • Watch the COMBAT COVID video.
  • Download a summary about monoclonal antibody treatment.